hmg coa reductase การใช้

• Statins block the HMG CoA reductase enzyme that is needed for the liver to produce cholesterol.
• Lovastatin was the first specific inhibitor of HMG CoA reductase to receive approval for the treatment of hypercholesterolemia.
• HMG CoA reductase occurs early in the biosynthetic pathway and is among the first committed steps to cholesterol formulation.
• Subsequent to the first reports describing mevastatin, efforts were initiated to search for other naturally occurring inhibitors of HMG CoA reductase.
• What statins do in the body, researchers found, is block an enzyme called HMG CoA reductase that helps the liver process cholesterol.
• They work by inhibiting an enzyme called HMG CoA reductase that is necessary for cholesterol production, resulting in a cholesterol deficit within liver cells.
• Oxysterols regulate cholesterol homeostasis through liver X receptor ( SCAP ) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins.
• They all work to lower blood levels of cholesterol by the same mechanism : They inhibit a liver enzyme called HMG CoA reductase that enables the liver to make cholesterol.
• The enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase ( HMG CoA reductase ) is an essential component and performs the first of 37 steps within the cholesterol production pathway, and present in every animal cell.
• They concluded suppression of mevalonate pathway activities, be it by modulators of HMG CoA reductase ( statins, tocotrienols, and farnesol ), farnesyl transferase ( farnesyl transferase inhibitors ), and / or mevalonate pyrophosphate decarboxylase ( phenylacetate ) activity, have a potential in pancreatic cancer chemotherapy.
• The first breakthrough in efforts to find a potent, specific, competitive inhibitor of HMG CoA reductase occurred in 1976, when Endo " et al . " reported the discovery of mevastatin, a highly functionalized fungal metabolite, isolated from cultures of " Penicillium citrium ".